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Research Associate CMC

Synaffix B.V. – Oss, North Brabant, The Netherlands (On-site) 


(0.8 – 1 FTE)


About the Company


Today, Lonza is a global leader in life sciences operating across three continents. While we work in science, there’s no magic formula to how we do it. Our greatest scientific solution is talented people working together, devising ideas that help businesses to help people. In exchange, we let our people own their careers. Their ideas, big and small, genuinely improve the world. And that’s the kind of work we want to be part of.


About the Job


We have an exciting opportunity available for a Research Associate CMC within the Chemistry Manufacturing and Control (CMC) group at Synaffix BV (a Lonza Company). The CMC group at Synaffix is responsible for the CMC activities that are required by our current and future partners in the development of their drug products, through clinical proof-of-concept and first-in-human testing. The CMC department has a central role within the organization with a focus on developing, manufacturing, and characterizing the components of the GlycoConnect platform and linker-payloads, as well as supporting of our partners with analytics for research, clinical development, and commercialization of Antibody Drug Conjugates (ADCs). We are looking for candidates with a passion for working in a chemical laboratory, with expertise in a broad range of synthetic techniques.


The Role


The Research Associate CMC will support the in-house and outsourced lab activities of the CMC department. The successful candidate will work closely with other researchers/scientists in an interdisciplinary team environment to help with all activities related to route scouting, process optimization, and scale-up in support of our ADC platform technology:

  • Design and execute multi-step synthesis and optimize through effective reaction planning, troubleshooting and systematic analysis. Perform proper documentation and accurate record-keeping of experimental data in an electronic lab journal.

  • Synthesize, purify and characterize compounds using a variety of techniques, including silica- and reversed phase column chromatography, crystallization, LCMS, NMR and HPLC.

  • Perform literature searches and stay abreast of recent advances in organic chemistry to contribute innovative solutions and improve synthetic strategies.

  • Write technical protocols and reports.

  • Prepare and revise analytical standard operating procedures (SOPs).

  • Support general CMC activities such as laboratory equipment maintenance, supply and inventory management.


Required qualifications:


  • Bachelor’s or Master’s degree in Organic Chemistry or a related scientific discipline.

  • Working experience of 0-5 years.

  • Strong laboratory skills and a high degree of attention to detail.

  • Good understanding of, and hands-on experience with, analytical techniques such as HPLC, LCMS and NMR.

  • Proficient in spoken and written English.

  • A responsible person with a proactive attitude who can work independently.

  • Being flexible, analytical, and well-organized.

  • A team player.




  • Should enjoy challenging situations and have the flexibility to work in a dynamic and fast-moving environment where there is the freedom to act.


Every day, Lonza’s products and services have a positive impact on millions of people. For us, this is not only a great privilege, but also a great responsibility. How we achieve our business results is just as important as the achievements themselves. At Lonza, we respect and protect our people and our environment. Any success we achieve is no success at all if not achieved ethically.

People come to Lonza for the challenge and creativity of solving complex problems and developing new ideas in life sciences. In return, we offer the satisfaction that comes with improving lives all around the world. The satisfaction that comes with making a meaningful difference.


For more details and applications, click here.


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