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PimBio: €0,5M for iPSC-based NMJ-on-a-chip model

Approximately 200.000 Dutch patients suffer from neuromuscular disorders (NMDs). Neuromuscular junctions (NMJs) are highly specialized structures that enable motor neurons to communicate with muscle fibers to establish muscle contraction. NMJ pathophysiology underlies muscle dysfunction in a range of NMDs such as amyotrophic lateral sclerosis, myasthenia gravis and Duchenne muscular dystrophy. The recent development of advanced therapies has been hampered by the lack of a robust NMJ model. PimBio is proud to announce that our NOACH (NMJ-On-A-CHip) consortium under the supervision of Dr. Maartje Huijbers has received a LUMC PPS-Match call Topsector LSH 2021 funding for the development of a patient-derived iPSC-based NMJs-on-a-chip model to study NMJ (patho)physiology by combining functional parameters with a relevant human genetic background. The NMJ-on-a-chip model will enable technology relevant for academic groups (basic research on disease mechanism, translational research) and for the industry (drug testing on human, patient-derived cells, personalized medicine, facilitation of FDA approval, phase IV trial in demonstrating effect of approved drugs). This project, supported by Stichting Proefdiervrij, will bridge the gap between 2D cell culture and animal models offering innovative and sustainable solutions with 3Rs potential to improve people’s lives.

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#100YEARSPHARMAFUTURE

The development of medicines in Oss began one hundred years ago. It was then that the foundations were laid for what would become a flourishing pharmaceutical sector in the Netherlands, leading to groundbreaking discoveries such as insulin and the anti-conception pill.

Today, the entire chain is still represented in Oss, from early-stage research to the commercial scale production of medicines. Working in Oss, we focus on the health of people all over the world. Employees at dozens of companies large and small put their heart and soul into new medicines, products and services that will improve lives worldwide. Together, our strength lies in our combination of broad knowledge about the development of medicines and a thorough understanding of the requirements of high-quality production.

This shared past and common values stimulate strong bonds among everyone who works in pharmaceuticals in Oss. We build on qualities, expertise and networks that go back decades. And with a wide variety of pharmaceutical companies, suppliers and scientific institutions all located nearby, we offer an attractive business climate and an excellent basis for international collaboration.

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Pharma in Oss offers endless opportunities to startups and talent in a city and region that is a joy to live and work in. We are committed to collaboration and sustainable and successful entrepreneurship. Oss’s pharmaceutical companies are intrinsically competitive while also being committed to quality and safety. This, plus their focus on new health solutions and contemporary technology, makes us a leader in our pursuit of a better life for people worldwide.