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Synaffix BV has signed an exclusive ADC licence agreement with Boehringer Ingelheim worth over $1.3 billion


Amsterdam, The Netherlands, Basel, Switzerland and Ingelheim, Germany, — Boehringer Ingelheim and Synaffix B.V., a Lonza company focused on commercializing its clinical-stage platform technology for the development of best-in-class antibody drug conjugates (ADCs), announced that Boehringer has licensed Synaffix’s ADC technology. This new partnership significantly bolsters Boehringer’s ADC portfolio, driven by its subsidiary, NBE Therapeutics, to achieve the company’s aim of transforming the lives of people with cancer.

ADCs are a cutting-edge class of cancer treatments that combine the targeting ability of antibodies with the potent cancer-killing power of drugs. This allows for the precise delivery of therapeutic agents directly to cancer cells, minimizing damage to healthy tissue and enhancing treatment efficacy.

Synaffix has developed a clinically validated ADC platform technology that utilizes an enzymatic modification of native glycan anchor points on antibodies, enabling the development of best-in-class ADCs or bispecifics. With the access to Synaffix’s technology, NBE Therapeutics broadens its ADC portfolio. This will enable Boehringer Ingelheim to address novel tumor targets from its comprehensive portfolio to develop first-in-class cancer treatments that address high unmet medical needs in oncology.

Under the terms of the agreement, Synaffix will provide access to its proprietary ADC technologies for an agreed but undisclosed number of targets. The first target was nominated upon signature, and additional targets will subsequently be nominated within a predefined timeframe. In addition to the upfront payment, Synaffix is eligible to receive potential additional milestone payments of up to $1.3 billion, plus additional royalty payments on net sales of resulting products.

Read the full press release here.

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