Senior Research Associate BioAnalytics

Citryll is a young and dynamic clinical stage therapeutic biotech company, located at the Pivot Park in Oss, The Netherlands. Citryll is taking a new approach to treat immune mediated inflammatory diseases including autoimmune diseases like Systemic Lupus Erythematosus (SLE), Rheumatoid Arthritis (RA), as well as skin and lung conditions. Citryll does this by specifically extinguishing the source of proinflammatory components, organ damaging components and autoantigens instead of broadly suppressing the acquired chronic inflammation.

Neutrophil extracellular traps (NETs), are part of the innate immune defense mechanisms but become pathogenic when their release is abundant and uncontrolled. Citryll’s lead anti-citrullinated histone antibody (ACHA) CIT-013 binds to N-terminal citrullinated epitopes on histones present in NETs, blocks NET formation, and promotes clearance of preformed NETs in tissues, all downstream of the protein citrullination pathway mediated by PAD enzymes. Inhibition of NET formation and accelerating clearance of preformed NETs reduces the exposure of autoantigens and toxic histones to the extracellular environment, leading to a decrease of proinflammatory mediators and protection of endothelial lining and organ tissue.

CIT-013 is a human antibody and is currently being tested in the clinic for safety & tolerability, PK and PD and the first clinical data have been evaluated. One proof of concept phase 2a clinical study is scheduled to start early 2023 and a second one later in 2023.

In Oss, the birthplace of many blockbuster drugs including the most successful PD1 antagonist antibody, we conduct various R&D elements of the CIT-013 program. This includes mechanism of action studies, research on new therapeutic use, bioanalytical assay development, clinical sample testing and pharmacological studies on patient neutrophils and whole blood.

You will work closely together with a small team of PhD scientists and (senior) research associates, and participate in:

  • Development and qualification of immunological and cell biological assays for (non)clinical sample analysis
  • Support the Bioanalytical team lead and assist in managing bioanalytical activities outsourced to CRO’s
  • Contribute to, and review scientific/bioanalytical protocols, reports, regulatory filings, SOPs and other guidelines;
  • Conduct scientific data review in accordance with current regulatory guidance and industry standards
  • Work closely together with CRO’s and contribute in managing outsourced regulated bioanalytical activities
    • [Keep track of critical timelines of bioanalytical activities together with the bioanalytical team lead]
    • Troubleshooting with respect to method development and initiation of improvements, where new ideas are valued
    • Supporting general laboratory activities
    • Presentation of experimental results and writing of development reports, and standard procedures (SOPs)
    • Full-time positions only (40 hours per week)

Competencies, qualifications and skills

  • BSc (HBO) or MSc (WO) or PhD degree in life sciences or related discipline.
  • ≥ 5 years of experience in a biotech or pharma company
  • Experience with assay development & qualification of cellular and immunological techniques like ELISA, Mesoscale Discovery and flow cytometry
  • Familiar with the regulatory guidelines for bioanalytical method development
  • Experience with transfer of bioanalytical methods to external service providers and familiarity with validation standards for bioanalytical assays
  • Proven excellent technical writing and oral communication skills in English
  • You are an accurate, flexible, quality-minded person that shows initiative and is able to work well in a team, as well as independently. You are goal oriented and result driven
  • You like to work in the environment of a dynamic biotech company where quality, speed, motivation, team spirit and results are of the utmost importance to be successful
  • You are or will be allowed to work in the EU.
  • Applicants without a permit to work in the EU or NL will not be considered

Please send your CV and a short motivation letter to Peter van Zandvoort ( Also, you can use this email address for informal enquiries about this vacancy before applying.

Please Note: Your personal information including your email address and CV will be kept on file during the hiring procedure but will be permanently deleted from our systems at the latest after 2 months of receiving it.

We will not consider recruitment agencies, please refrain from contacting us through email, phone, WhatsApp or LinkedIn or any other means.

Pivot Park Captains' Dinner

10 years ago, Pivot Park opened its doors to the world. Thanks to your commitment, support and confidence, we have been able to grow it into the successful and innovative biopharmaceutical campus it is today.

Now it’s time to celebrate!

We are therefore delighted to invite you – along with all your fellow CEOs at Pivot Park – to a special night out featuring inspiring art, a wonderful dinner and lots of opportunities to network and exchange ideas.

Erwin Wurm | Am I a House?

For the first time, the artist shows a cross-section of his work, from Narrow Furniture to One Minute Sculptures, within the walls of a historic building. Villa Constance, a former home that today houses Museum Jan Cunen, is not only a location but also part of the conversation. Because what exactly is a house?


The development of medicines in Oss began one hundred years ago. It was then that the foundations were laid for what would become a flourishing pharmaceutical sector in the Netherlands, leading to groundbreaking discoveries such as insulin and the anti-conception pill.

Today, the entire chain is still represented in Oss, from early-stage research to the commercial scale production of medicines. Working in Oss, we focus on the health of people all over the world. Employees at dozens of companies large and small put their heart and soul into new medicines, products and services that will improve lives worldwide. Together, our strength lies in our combination of broad knowledge about the development of medicines and a thorough understanding of the requirements of high-quality production.

This shared past and common values stimulate strong bonds among everyone who works in pharmaceuticals in Oss. We build on qualities, expertise and networks that go back decades. And with a wide variety of pharmaceutical companies, suppliers and scientific institutions all located nearby, we offer an attractive business climate and an excellent basis for international collaboration.

We are proud to work together to create a better and healthier future for all, a collaboration that in turn fuels growing employment: today, most pharmaceutical jobs in the Netherlands are in Oss. Here we connect talent and companies and stimulate entrepreneurship, while our expert employees are our most important asset. Their drive ensures that Oss has an influence on health all over the world.

Pharma in Oss offers endless opportunities to startups and talent in a city and region that is a joy to live and work in. We are committed to collaboration and sustainable and successful entrepreneurship. Oss’s pharmaceutical companies are intrinsically competitive while also being committed to quality and safety. This, plus their focus on new health solutions and contemporary technology, makes us a leader in our pursuit of a better life for people worldwide.