Scientist Crystallography

Lead Pharma develops innovative small-molecule therapies for patients with autoimmune disease or cancer. Lead Pharma is headquartered at Pivot Park, the biopharmaceutical life sciences campus in Oss, the Netherlands. Lead Pharma has fully equipped labs for all stages of drug discovery, including medicinal chemistry, cellular pharmacology, and molecular pharmacology, as well as an in-silico lab for their computational chemistry, bioinformatics, and data mining activities. Lead Pharma works with a select network of specialized contract research organizations to whom we outsource in vivo pharmacology and toxicology studies.

Lead Pharma has a qualified team of 30 employees, including 10 with a Ph.D. degree, who have long-term experience working in large pharmaceutical companies, biotech companies, and academia.

For its Medicinal Chemistry Laboratory, located at the Pivot Park in Oss, The Netherlands, Lead Pharma is looking to recruit a skilled and enthusiastic.

Scientist Crystallography

(full time)

Position in the organization
The Scientist will report to the Group Leader Cellular Pharmacology & Molecular Pharmacology.

The role
This role covers the entire scope of protein X-ray crystallography, including molecular biology, protein expression, and purification, protein crystal growth, operation of the in-house X-ray diffractometer to collect data sets, and determination of protein: ligand structures to support small molecule drug development.

Key responsibilities

  • Initiate, execute, manage, and be co-responsible for protein X-ray crystallography;
  • Act as a subject matter expert for protein X-ray crystallography, molecular biology, and protein sciences, supporting colleagues with experimental design when needed;
  • Implement protein: ligand structural information to guide in-house drug development within drug discovery project teams;
  • Contribute actively to and liaise with technology and project teams.

Your profile
Key requirements are:

  • A Ph.D. in protein X-ray crystallography, structural biology, biophysical chemistry, or a related field;
  • More than 3 years experience in protein X-ray crystallography in academia or in the industry;
  • Direct experience with gene to structure projects;
  • A good team player who is able to work effectively with others within a multidisciplinary environment;
  • Excellent communication and presentation skills in English;
  • Effective organization skills;
  • Proactive mindset.

The following working experience will give you an advantage:

  • Experience in determining protein: ligand structures to guide small molecule compound design or understand protein function.
  • Experience with biophysical methods such as direct binding kinetics.

The role is based in Oss, the Netherlands and the appointed candidate will be expected to spend most of his/her time at this location.

When you are interested in this position, please send your motivation letter together with your resume to By sending us your personal details you allow us to process these in our systems conform the GDPR legislation.
Further information can be obtained from the group leader Molecular and Cellular Pharmacology: Dr. Sanne van Zanten: +31(0)412 782 992.

Acquisition as a result of this vacancy is not appreciated


The development of medicines in Oss began one hundred years ago. It was then that the foundations were laid for what would become a flourishing pharmaceutical sector in the Netherlands, leading to groundbreaking discoveries such as insulin and the anti-conception pill.

Today, the entire chain is still represented in Oss, from early-stage research to the commercial scale production of medicines. Working in Oss, we focus on the health of people all over the world. Employees at dozens of companies large and small put their heart and soul into new medicines, products and services that will improve lives worldwide. Together, our strength lies in our combination of broad knowledge about the development of medicines and a thorough understanding of the requirements of high-quality production.

This shared past and common values stimulate strong bonds among everyone who works in pharmaceuticals in Oss. We build on qualities, expertise and networks that go back decades. And with a wide variety of pharmaceutical companies, suppliers and scientific institutions all located nearby, we offer an attractive business climate and an excellent basis for international collaboration.

We are proud to work together to create a better and healthier future for all, a collaboration that in turn fuels growing employment: today, most pharmaceutical jobs in the Netherlands are in Oss. Here we connect talent and companies and stimulate entrepreneurship, while our expert employees are our most important asset. Their drive ensures that Oss has an influence on health all over the world.

Pharma in Oss offers endless opportunities to startups and talent in a city and region that is a joy to live and work in. We are committed to collaboration and sustainable and successful entrepreneurship. Oss’s pharmaceutical companies are intrinsically competitive while also being committed to quality and safety. This, plus their focus on new health solutions and contemporary technology, makes us a leader in our pursuit of a better life for people worldwide.