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10 years Pivot Park: BioConnection

BioConnection’s operational expertise is filling vials and syringes for small to medium-sized pharmaceutical companies and Bio-techs. In 17 years since it was founded, this Contract Development and Manufacturing Organisation (CDMO) has grown into a major company with a global customer base.

Perfect infrastructure is essential

BioConnection’s operational expertise is filling vials and syringes for small to medium-sized pharmaceutical companies and Bio-techs. In 17 years since it was founded, this CDMO has grown into a major company with a global customer base. “BioConnection was founded by Organon, BOM and Mibiton” says Alexander Willemse. He further explains that filling medicines in vials and syringes is all about precision and conforming to extremely strict guidelines outlined in Good Manufacturing Practice (GMP). Each individual drug requires its own bespoke production settings on the filling line which has to be set up separately. Accuracy and attention to the minutest detail are vital.

In the past, MSD/Organon started the clinical production in a separate building, also known as the RY building, the Aletta Jacobs building or, very recognizable, known as ‘the big red building’ in Oss. In order to help young biotechs and startups, Organon/MSD made a part of the building’s capacity available to the outside. So in 2005, BioConnection was established. The initial housing was arranged in the management building of Organon just outside the premises. This was well before the time of Pivot Park. The deal was easy; BioConnection could offer the expertise and capabilities of the Organon labs and its assigned part of the production capacity to the market. The set-up and RY production facility was completed within the same year. Not by coincidence; the day of opening of the RY building was the day of incorporation of BioConnection.

A productive move to Pivot Park.
After a productive start, challenging times followed especially between 2010 and 2016. The future of Pivot Park wasn’t certain and neither was the success of BioConnection. But BioConnection continued to grow. Even at such a pace that two times in a row a Gazelle Award was won. In 2016 disaster was about to strike when MSD determined that it had no use for the RY building anymore and intended to end manufacturing by 2016 at the latest. However, Willemse saw a bright future for the company. Through the help of various investors such as the BOM and Mibiton, he managed to keep the company building open and in 2016 BioConnection was able to take over the MSD factory while the ownership of the location transferred to Pivot Park. It must be noted that MSD assisted BioConnection in a smooth and ‘warm’ transfer of the RY building and supported BioConnection with services for the first 2 years. From that point onwards, BioConnection was an independent company, and an extremely successful one. Willemse explains, “In 2005 we began with 2 people and at the beginning of 2016 we had 6 employees and we ended the year with 21. By 2022 we had grown to 90 employees.”

With this huge increase in staff, the number of square meters BioConnection required at Pivot Park also increased dramatically. “In 2020, we opened a brand new production line on the third floor of the RY building,” says Willemse. “BioConnection has evolved from a broker with limited production capacity into a full manufacturing company offering its own services to small and medium-sized (and sometimes big) pharmaceutical organizations and biotech companies worldwide. The cornerstones of our CMC services are: Fill and Finish, Freeze Drying, Finished Product Services and Drug Product Development.”

Our core business begins and ends with Fill & Finish
“Fill and Finish remains our core business. We can produce runs of 1 to 150,000 vials per day. Additionally we offer freeze-dry services for vials and also have a significant capacity for syringe filling. To summarize, the ingredients and the ideas come from our clients and we put it in vials or syringes. We also offer handfill services where, with relatively small amounts, we are a perfect fit for Personalized Medicines , a form of therapies and products that has seen a recent rise in demand.” BioConnection serves a large international clientele. Willemse continues, “It is essential that we not only comply with the European guidelines regarding GMP, but also with those of the U.S. Food and Drug Administration, the FDA. So we can work for major clients in the US, but, more important, the products produced for any customer on our filling lines can be exported to the US market.” He believes it is important that BioConnection continues to grow so that a good infrastructure for developing medicines in the Netherlands remains in place. “Because if anything has become clear in recent years, it is how important research and development of new medicines and vaccines is not only from a Dutch or European perspective but worldwide. We can maximize knowledge and efficiencies of scale by having the entire chain from R&D to production also here.”

BioConnection offers young, innovative bio-pharmaceutical companies access to a state-of-the-art-GMP manufacturing facility and a broad range of support services. BioConnection is a contract services and manufacturing organisation focused on the development and manufacture (Filling and Freeze drying) of injectable (bio)pharmaceutical products. From its proprietary site in Oss the company supplies both clinical as commercial products to a worldwide customer base (FDA/EMA).

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Pivot Park Captains' Dinner

10 years ago, Pivot Park opened its doors to the world. Thanks to your commitment, support and confidence, we have been able to grow it into the successful and innovative biopharmaceutical campus it is today.

Now it’s time to celebrate!

We are therefore delighted to invite you – along with all your fellow CEOs at Pivot Park – to a special night out featuring inspiring art, a wonderful dinner and lots of opportunities to network and exchange ideas.

Erwin Wurm | Am I a House?

For the first time, the artist shows a cross-section of his work, from Narrow Furniture to One Minute Sculptures, within the walls of a historic building. Villa Constance, a former home that today houses Museum Jan Cunen, is not only a location but also part of the conversation. Because what exactly is a house?


The development of medicines in Oss began one hundred years ago. It was then that the foundations were laid for what would become a flourishing pharmaceutical sector in the Netherlands, leading to groundbreaking discoveries such as insulin and the anti-conception pill.

Today, the entire chain is still represented in Oss, from early-stage research to the commercial scale production of medicines. Working in Oss, we focus on the health of people all over the world. Employees at dozens of companies large and small put their heart and soul into new medicines, products and services that will improve lives worldwide. Together, our strength lies in our combination of broad knowledge about the development of medicines and a thorough understanding of the requirements of high-quality production.

This shared past and common values stimulate strong bonds among everyone who works in pharmaceuticals in Oss. We build on qualities, expertise and networks that go back decades. And with a wide variety of pharmaceutical companies, suppliers and scientific institutions all located nearby, we offer an attractive business climate and an excellent basis for international collaboration.

We are proud to work together to create a better and healthier future for all, a collaboration that in turn fuels growing employment: today, most pharmaceutical jobs in the Netherlands are in Oss. Here we connect talent and companies and stimulate entrepreneurship, while our expert employees are our most important asset. Their drive ensures that Oss has an influence on health all over the world.

Pharma in Oss offers endless opportunities to startups and talent in a city and region that is a joy to live and work in. We are committed to collaboration and sustainable and successful entrepreneurship. Oss’s pharmaceutical companies are intrinsically competitive while also being committed to quality and safety. This, plus their focus on new health solutions and contemporary technology, makes us a leader in our pursuit of a better life for people worldwide.